scores for synapses positive for SERT/talin colocalization (data introduced on the very best of graph as the signify ± SEM; unpaired t
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Our laboratory shown that SERT and αvβ3 receptors colocalize in midbrain presynaptic terminals (Mazalouskas et al., 2015), suggesting that SERT is localized to multiprotein complexes coordinated by integrin αvβthree in midbrain synapses. Previous reports propose that in platelets, the Affiliation of SERT with activated αIIbβthree integrins, and its localization to adhesion complexes, are correlated with enhanced uptake action (Carneiro et al.
Major genotype variations in the amount of synapses are indicated in italics. Structured illumination microscopy of WT and KI midbrain slices was accustomed to quantify the colocalization of your outlined proteins within just SERT-favourable synapses.
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